PittsburghV1, Canada, Analysis, bibRecord, 000619

Factors Associated With the Persistence and Onset of New Anxiety Disorders in Youth With Bipolar Spectrum Disorders

Identifieur interne : 000619 ( Canada/Analysis ); précédent : 000618; suivant : 000620

Factors Associated With the Persistence and Onset of New Anxiety Disorders in Youth With Bipolar Spectrum Disorders

Auteurs : Regina Sala [États-Unis] ; David A. Axelson [États-Unis] ; Josefina Castro-Fornieles [Espagne] ; Tina R. Goldstein [États-Unis] ; Benjamin I. Goldstein [Canada] ; Wonho Ha [États-Unis] ; FANGZI LIAO [États-Unis] ; Mary Kay Gill [États-Unis] ; Satish Lyengar [États-Unis] ; Michael A. Strober [États-Unis] ; Shirley Yen [États-Unis] ; Heather Hower [États-Unis] ; Jeffrey I. Hunt [États-Unis] ; Daniel P. Dickstein [États-Unis] ; Neal D. Ryan [États-Unis] ; Martin B. Keller [États-Unis] ; Boris Birmaher [États-Unis]

Source :

The Journal of clinical psychiatry [ 0160-6689 ] ; 2012.

RBID : Pascal:12-0095684

Descripteurs français

Pascal (Inist)
- Trouble anxieux, Trouble bipolaire, Spectre bipolaire.

English descriptors

KwdEn :
- Anxiety disorder, Bipolar disorder.

Abstract

Objective: Anxiety disorders are among the most common comorbid conditions in youth with bipolar disorder, but, to our knowledge, no studies examined the course of anxiety disorders in youth and adults with bipolar disorder. Method: As part of the Course and Outcome of Bipolar Youth study, 413 youth, ages 7 to 17 years who met criteria for Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) bipolar I disorder (n=24_4), bipolar II disorder (n=28)_, and operationally defined bipolar disorder not otherwise specified (n=141 ₎ were recruited primarily from outpatient clinics. Subjects were followed on average for 5 years using the Longitudinal Interval Follow-Up Evaluation. We examined factors associated with the persistence (> 50% of the follow-up time) and onset of new anxiety disorders in youth with bipolar disorder. Results: Of the 170 youth who had anxiety at intake, 80.6% had an anxiety disorder at any time during the follow-up. Most of the anxiety disorders during the follow-up were of the same type as those present at intake. About 50% of the youth had persistent anxiety, particularly generalized anxiety disorder (GAD). Persistence was associated with multiple anxiety disorders, less follow-up time in euthymia, less conduct disorder, and less treatment with antimanic and antidepressant medications (all P values ≤.05). Twenty-five percent of the sample who did not have an anxiety disorder at intake developed new anxiety disorders during follow-up, most commonly GAD. The onset of new anxiety disorders was significantly associated with being female, lower socioeconomic status, presence of attention-deficit/hyperactivity disorder and substance use disorder, and more follow-up time with manic or hypomanic symptoms (all P values ≤.05) Conclusions: Anxiety disorders in youth with bipolar disorder tend to persist, and new-onset anxiety disorders developed in a substantial proportion of the sample. Early identification of factors associated with the persistence and onset of new anxiety disorders may enable the development of strategies for treatment and prevention.

Affiliations:

Links to Exploration step

Pascal:12-0095684

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Factors Associated With the Persistence and Onset of New Anxiety Disorders in Youth With Bipolar Spectrum Disorders</title>
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<country>États-Unis</country>
<wicri:noRegion>Department of Psychiatry and BiobehavioralSciences, David Geffen School of Medicine, University of California at Los Angeles</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yen, Shirley" sort="Yen, Shirley" uniqKey="Yen S" first="Shirley" last="Yen">Shirley Yen</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Psychiatry and Butler Hospital, Brown University School of Medicine</s1>
<s2>Providence, Rhode Island</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Rhode Island</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hower, Heather" sort="Hower, Heather" uniqKey="Hower H" first="Heather" last="Hower">Heather Hower</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Psychiatry and Butler Hospital, Brown University School of Medicine</s1>
<s2>Providence, Rhode Island</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Rhode Island</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hunt, Jeffrey I" sort="Hunt, Jeffrey I" uniqKey="Hunt J" first="Jeffrey I." last="Hunt">Jeffrey I. Hunt</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Psychiatry and Butler Hospital, Brown University School of Medicine</s1>
<s2>Providence, Rhode Island</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Rhode Island</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dickstein, Daniel P" sort="Dickstein, Daniel P" uniqKey="Dickstein D" first="Daniel P." last="Dickstein">Daniel P. Dickstein</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Psychiatry and Butler Hospital, Brown University School of Medicine</s1>
<s2>Providence, Rhode Island</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Rhode Island</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ryan, Neal D" sort="Ryan, Neal D" uniqKey="Ryan N" first="Neal D." last="Ryan">Neal D. Ryan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Keller, Martin B" sort="Keller, Martin B" uniqKey="Keller M" first="Martin B." last="Keller">Martin B. Keller</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Psychiatry and Butler Hospital, Brown University School of Medicine</s1>
<s2>Providence, Rhode Island</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Rhode Island</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Birmaher, Boris" sort="Birmaher, Boris" uniqKey="Birmaher B" first="Boris" last="Birmaher">Boris Birmaher</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The Journal of clinical psychiatry</title>
<title level="j" type="abbreviated">J. clin. psychiatry</title>
<idno type="ISSN">0160-6689</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Journal of clinical psychiatry</title>
<title level="j" type="abbreviated">J. clin. psychiatry</title>
<idno type="ISSN">0160-6689</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anxiety disorder</term>
<term>Bipolar disorder</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Trouble anxieux</term>
<term>Trouble bipolaire</term>
<term>Spectre bipolaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: Anxiety disorders are among the most common comorbid conditions in youth with bipolar disorder, but, to our knowledge, no studies examined the course of anxiety disorders in youth and adults with bipolar disorder. Method: As part of the Course and Outcome of Bipolar Youth study, 413 youth, ages 7 to 17 years who met criteria for Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) bipolar I disorder (n=24<sub>4),</sub>
 bipolar II disorder (n=28)<sub>,</sub>
 and operationally defined bipolar disorder not otherwise specified (n=141 <sub>)</sub>
 were recruited primarily from outpatient clinics. Subjects were followed on average for 5 years using the Longitudinal Interval Follow-Up Evaluation. We examined factors associated with the persistence (> 50% of the follow-up time) and onset of new anxiety disorders in youth with bipolar disorder. Results: Of the 170 youth who had anxiety at intake, 80.6% had an anxiety disorder at any time during the follow-up. Most of the anxiety disorders during the follow-up were of the same type as those present at intake. About 50% of the youth had persistent anxiety, particularly generalized anxiety disorder (GAD). Persistence was associated with multiple anxiety disorders, less follow-up time in euthymia, less conduct disorder, and less treatment with antimanic and antidepressant medications (all P values ≤.05). Twenty-five percent of the sample who did not have an anxiety disorder at intake developed new anxiety disorders during follow-up, most commonly GAD. The onset of new anxiety disorders was significantly associated with being female, lower socioeconomic status, presence of attention-deficit/hyperactivity disorder and substance use disorder, and more follow-up time with manic or hypomanic symptoms (all P values ≤.05) Conclusions: Anxiety disorders in youth with bipolar disorder tend to persist, and new-onset anxiety disorders developed in a substantial proportion of the sample. Early identification of factors associated with the persistence and onset of new anxiety disorders may enable the development of strategies for treatment and prevention.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Espagne</li>
<li>États-Unis</li>
</country>
<region><li>Catalogne</li>
<li>Ontario</li>
<li>Pennsylvanie</li>
<li>Rhode Island</li>
</region>
<settlement><li>Barcelone</li>
<li>Pittsburgh</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Sala, Regina" sort="Sala, Regina" uniqKey="Sala R" first="Regina" last="Sala">Regina Sala</name>
</noRegion>
<name sortKey="Axelson, David A" sort="Axelson, David A" uniqKey="Axelson D" first="David A." last="Axelson">David A. Axelson</name>
<name sortKey="Birmaher, Boris" sort="Birmaher, Boris" uniqKey="Birmaher B" first="Boris" last="Birmaher">Boris Birmaher</name>
<name sortKey="Dickstein, Daniel P" sort="Dickstein, Daniel P" uniqKey="Dickstein D" first="Daniel P." last="Dickstein">Daniel P. Dickstein</name>
<name sortKey="Fangzi Liao" sort="Fangzi Liao" uniqKey="Fangzi Liao" last="Fangzi Liao">FANGZI LIAO</name>
<name sortKey="Gill, Mary Kay" sort="Gill, Mary Kay" uniqKey="Gill M" first="Mary Kay" last="Gill">Mary Kay Gill</name>
<name sortKey="Goldstein, Tina R" sort="Goldstein, Tina R" uniqKey="Goldstein T" first="Tina R." last="Goldstein">Tina R. Goldstein</name>
<name sortKey="Ha, Wonho" sort="Ha, Wonho" uniqKey="Ha W" first="Wonho" last="Ha">Wonho Ha</name>
<name sortKey="Hower, Heather" sort="Hower, Heather" uniqKey="Hower H" first="Heather" last="Hower">Heather Hower</name>
<name sortKey="Hunt, Jeffrey I" sort="Hunt, Jeffrey I" uniqKey="Hunt J" first="Jeffrey I." last="Hunt">Jeffrey I. Hunt</name>
<name sortKey="Keller, Martin B" sort="Keller, Martin B" uniqKey="Keller M" first="Martin B." last="Keller">Martin B. Keller</name>
<name sortKey="Lyengar, Satish" sort="Lyengar, Satish" uniqKey="Lyengar S" first="Satish" last="Lyengar">Satish Lyengar</name>
<name sortKey="Ryan, Neal D" sort="Ryan, Neal D" uniqKey="Ryan N" first="Neal D." last="Ryan">Neal D. Ryan</name>
<name sortKey="Strober, Michael A" sort="Strober, Michael A" uniqKey="Strober M" first="Michael A." last="Strober">Michael A. Strober</name>
<name sortKey="Yen, Shirley" sort="Yen, Shirley" uniqKey="Yen S" first="Shirley" last="Yen">Shirley Yen</name>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Castro Fornieles, Josefina" sort="Castro Fornieles, Josefina" uniqKey="Castro Fornieles J" first="Josefina" last="Castro-Fornieles">Josefina Castro-Fornieles</name>
</region>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Goldstein, Benjamin I" sort="Goldstein, Benjamin I" uniqKey="Goldstein B" first="Benjamin I." last="Goldstein">Benjamin I. Goldstein</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Factors Associated With the Persistence and Onset of New Anxiety Disorders in Youth With Bipolar Spectrum Disorders

Factors Associated With the Persistence and Onset of New Anxiety Disorders in Youth With Bipolar Spectrum Disorders

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